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How organs grow: Amazing timelapse reveals cells spreading out like tree branches in a KIDNEY
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How organs grow: Amazing timelapse reveals cells spreading out like tree branches in a KIDNEY
University of Edinburgh scientists took time-lapse kidney growth images
They reveal structures called nephrons branching out like a tree
These are instructed to do so by a key protein called beta-catenin
By altering the protein activity, the researchers found that they could instruct the kidney to grow slightly differently
The findings could reveal more about how kidneys function
By JONATHAN O’CALLAGHAN FOR MAILONLINE
Striking images have revealed new insights into how the kidney develops from a group of cells into a complex organ.
In a time-lapse video, a mouse kidney is seen developing, with cells growing out like the branches of a tree.
It is hoped the images will help scientists to understand the early stages of development in mammals.
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Researchers at the University of Edinburgh’s Roslin Institute used time-lapse imaging to capture mouse kidneys growing in the laboratory on camera.
They identified a key protein called beta-catenin that instructs cells to form specialised structures within the kidney.
These structures – called nephrons – are responsible for filtering waste products from the blood to generate urine.
Yellow areas in the video show where beta-catenin is most active, with higher concentrations instructing cells to form particular parts of the structure.
The images reveal that a gradient in the activity of beta-catenin forms along the growing nephron. It is the concentration of the molecule that instructs cells to form each particular part of the structure.
By changing the activity of beta-catenin in different places, the researchers learned that they could instruct cells to form the kidney in different ways.
If nephrons do not work correctly, it can lead to a wide range of health problems – from abnormal water and salt loss, to dangerously high blood pressure.
The findings will help scientists to grow nephrons in the lab that can be used to study how kidneys function….More Here
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