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How memories are REALLY made: Incredible images reveal synapses strengthening inside mice brains
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How memories are REALLY made: Incredible images reveal synapses strengthening inside mice brains
Scientists from Johns Hopkins University in Baltimore created mice with brain receptors that glowed under the light of a special microscope
Receptors help nerve cells strengthen their connections to form memories
They were able to see nerve cells clearly, to observe how memories form
This has been previously impossible, until the new imaging technique
Images show that tickling the whiskers of mice increased the number of AMPA receptors on their nerve cells – forming memories
By SARAH GRIFFITHS FOR MAILONLINE
Scientists have managed to peer into the brains of mice so clearly that they watch as memories are formed.
They saw how certain proteins changed and clustered on nerve cells, as memories were forged after tickling the creatures’ whiskers.
The technique could shed light on how we learn as well as what goes wrong in disorders like autism, Alzheimer’s disease and schizophrenia.
‘As far as we know, no one has ever been able to look at receptor proteins in live animals before,’ said Professor Richard Huganir, director of the Department of Neuroscience at the Johns Hopkins University School of Medicine.
‘This allows us to get a more accurate picture of what’s really happening as the brain processes experiences into memories.’
Researchers at the university in Baltimore, Maryland, studied AMPA receptors, which are proteins on the outside of nerve cells that receive signals in the form of the molecule glutamate.
Glutamate is the major mediator of electrical signals in the central nervous systems of mammals and is involved in most aspects of normal brain function including cognition, memory and learning.
The receptors themselves play a role in strengthening synapses, which are the connections between nerve cells that form memories.
Up until now, scientists were limited to studying AMPA receptors in nerve cells in tissue samples, or grown in the laboratory, but neither of those methods could preserve the complex circuitry, hormones and neurochemicals of a living brain….More Here
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