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New compound rapidly eliminates malaria parasite: Study
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New compound rapidly eliminates malaria parasite: Study
A new study suggests that a new anti-malarial compound quickly eliminates malaria parasite. (File photo)
A new study says a promising anti-malarial compound can rapidly kill red blood cells infected with the malaria parasite while leaving healthy cells unharmed.
The study, which appeared online in the journal, Proceedings of the National Academy of Sciences (PNAS), suggests that the compound can inhibit the activity of the ATP4 protein in Plasmodium falciparum, the deadliest of the malaria parasites.
Disrupting ATP4 helps the immune system kill the infected red blood cells, the study noted.
“The data suggest that compounds targeting ATP4 induce physical changes in the infected red blood cells that allow the immune system or erythrocyte quality control mechanisms to recognize and rapidly eliminate infected cells,” said co-author, Joseph DeRisi, a Howard Hughes Medical Institute investigator.
However, he said, “This rapid clearance response depends on the presence of both the parasite and the investigational drug. That is important because it leaves uninfected red blood cells, also known as erythrocytes, unharmed.”
Corresponding author, R. Kiplin Guy, from St. Jude Children’s Research Hospital in the US, said: “Our goal is to develop an affordable, fast-acting combination therapy that cures malaria with a single dose,” reported the Business Standard.
The compound was developed from a molecule detected in a previous study from St. Jude Children’s Research Hospital. It is planned to undergo clinical trials.
Source: www.presstv.ir
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